We surmise that results obtained from the experiments described in this section cannot serve to understand the role of INaL in arrhythmogenesis.
1. Van Driessche W, Lindemann B: Focus dependence of currents compliment of unmarried sodium-choosy pores for the frog skin. Character. 1979; 282 (5738): 519-520 PubMed Conceptual | Creator Full Text message
This means the brand new solid conclusions put forward from this manuscript is actually perhaps not warranted and that i do not agree this new manuscript within means
Brand new authors possess explained a number of the inquiries I increased in my personal prior remark. Sadly, all the biggest problems have not been treated from this posting. Once i made in my personal early in the day comment, I consider it unrealistic that all those people situations shall be repaired just by the several added paragraphs. Alternatively there are still particular simple concerns on experimental framework and you will, extremely significantly, on study.
It means the latest strong findings submit through this manuscript is actually not warranted and i never agree the fresh new manuscript inside means
Brand new article authors keeps clarified a number of the questions I increased for the my previous feedback. Unfortuitously, all major difficulties haven’t been handled from this up-date. Once i made in my personal prior remark, We consider they unlikely that every those people circumstances is going to be set simply from the a few additional sentences. Alternatively there are still specific simple inquiries to your experimental framework and you may, very vitally, into data.
- Ideal issue is that if I followed the newest dysfunction of the ways in the previous version it absolutely was you are able to to help you decode, with nearly write my coursework for me prime precision, any random stimulus brands We picked. See to have examples of that it reanalysis. No matter whether i imagine your real stimuli looked at the a later on day or try consistently alternating anywhere between rule and you may quiet, the latest decryption is obviously near to primary. This is certainly an indication that decoding has nothing accomplish on genuine stimulus heard from the Sender it is opportunistically exploiting various other has from the research. The newest control investigation new authors performed, reversing the stimuli labels, dont target this matter because it is suffering from exactly the same condition. Basically, just what classifier are presumably using is the time who’s introduced due to the fact recording become.
- The explanation for this really is allegedly that experts utilized low-separate studies having training and you will testing. And in case I know truthfully (come across section step 3), haphazard testing half of information examples of an enthusiastic EEG shadow aren’t independent studies. Recurring the research five times – this new manage data this new article authors did – isn’t an acceptable cure for address it matter. At random looking products off a period series who has slow changes (like the sluggish revolution interest you to presumably dominates such recordings less than these circumstances) commonly invariably consist of solid temporal correlations. Come across TemporalCorrelations.jpg in for 2D density histograms and you can a relationship matrix proving which.
- Because changed tips part brings increased detail today, they remains confused about exactly what investigation were utilized. Antique group data statement just what studies features (usual articles about research matrix) and you will exactly what findings (common rows) were utilized. Some thing will be a feature however, normally that is the various other EEG channels otherwise fMRI voxels etc. Findings are often big date facts. Here I suppose the fresh new article writers turned the latest intense examples on the an effective some other space using dominating part research. This isn’t mentioned if your dimensionality is actually shorter making use of the eigenvalues. Regardless, I assume the data samples (accumulated at 128 Hz) were then made use of as the findings and EEG channels switched of the PCA were utilized once the has. The fresh new stimulus brands was basically tasked as To the or From per take to. A collection of fifty% off examples (and you may labels) ended up being chosen at random to possess training, and the rest was used to possess investigations. So is this best?